Single-dose amoxicillin therapy for urinary tract infection. Multicenter trial using antibody-coated bacteria localization technique

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Abstract
Urine specimens from 134 women with acute, uncomplicated urinary tract infection at 3 medical centers were examined by the antibody-coated bacteria (ACB) assay. Patients with negative assays (suggesting bladder infection alone) were randomized to receive a single 3 g oral dose of amoxicillin trihydrate or conventional 10 day courses of sulfamethoxazole-trimethoprim or oral ampicillin sodium. Comparable results were obtained with the 3 regimens for ACB-negative infection: 90% eradication of the original organism with single-dose amoxicillin, 100% with sulfamethoxazole-trimethoprim and 96% with ampicillin. The overall incidence of ACB positivity was 32.1%, ranging from 8-63% at the 3 institutions. This difference seemed to be related to the ease of access to medical care: women with easy access having low rates of ACB positivity and those with poor access having high rates.