In vivo silencing of alpha-synuclein using naked siRNA
Open Access
- 1 January 2008
- journal article
- Published by Springer Nature in Molecular Neurodegeneration
- Vol. 3 (1) , 19
- https://doi.org/10.1186/1750-1326-3-19
Abstract
Overexpression of α-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem. Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a result of overexpression. SNCA downregulation is therefore a valid therapeutic target for PD.Keywords
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