SPECTROPHOTOFLUOROMETRIC METHOD FOR QUANTITATIVE-DETERMINATION OF SULPIRIDE IN HUMAN-PLASMA AND URINE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 8  (2) , 104-110
Abstract
The plasma concentrations (0-24 h) and renal excretions (0-48 h) for sulpiride [S] were measured after Dogmatil forte or Sulpiril tablets both containing 200 mg of sulpiride, after 2 Sulpiril capsules containing 50 mg of S in each capsules containing 50 mg S in each capsule, and after 20 ml Dogmatil saft and 20 ml Sulpiril mix [mixture] both containing 5 mg/ml of S. There were no significant differences in the S concentrations in plasma or cumulative urinary excretion of S after Dogmatil forte (200 mg S) or Sulpiril tablet (200 mg S). Two Sulpiril capsules (100 mg S) produced significantly lower plasma concentrations of S at 3 h than a Sulpiril tablet (200 mg S) and these were also lower at 4 and 6 h than with either a Dogmatil forte (200 mg S) or a Sulpiril tablet (200 mg S). Two Sulpiril capsules (100 mg S) gave significantly higher plasma S concentrations from 1-6 h than 20 ml Sulpiril mixt (100 mg S) and from 2-6 h higher than 20 ml Dogmatil saft (100 mg S). The plasma half-life of S measured after 2 Sulpiril capsules, 20 ml Dogmatil saft, and 20 ml Sulpiril mixt, was 9.4 h, 9.5 h and 10.2 h, respectively. The renal excretion of S after 2 Sulpiril capsules (100 mg S) were significantly lower than after a sulpiril tablet (200 mg S) from 8-48 h, and also significantly lower than after a Dogmatil forte tablet (200 mg S) from 24-48 h. Two Sulpiril capsules (100 mg S) gave significantly higher S urine concentrations from 8-24 h than 20 ml Sulpiril mixt (100 mg S) and from 24-48 h than 20 ml Dogmatil saft (100 mg S). There were no significant differences in this respect between either a Dogmatil forte tablet (200 mg S) and A sulpiril tablet (200 mg S) or between Dogmatil saft (100 mg S) and Sulpiril mixt (100 mg S). Compared with a Dogmatil forte tablet, the bioavailability, calculated by the AUC24 [total area under the plasma drug concentration-time curves from 0-24 h] for a Sulpiril tablet was 159%, for a Sulpiril capsule 118%, for Dogmatil saft 7, and for Sulpiril mixt 89%. The same values calculated from the sulpiride urine concentrations were 118%, 114%, 71% and 67%, respectively. There were no significant differences in the blood pressure or heart rate of the volunteers during the experiment. Two volunteers reported a sedative effect after a Dogmatil forte tablet.

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