Photosensitivity to piroxicam: absence of cross‐reaction with tenoxicam

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Abstract
We studied 2 groups of patients. One group or 10 patients had a photosensitive eruption to piroxicam. Another group of 24 patients had positive patch test reactions to thimerosal and thiosalicylie acid and had never taken piroxicam or tenoxicam. Patients were patch tested with thimerosal 0.1% pet., thiasalicylic acid 0.1% pet., salicylic acid 2.0% pet., piroxicam 1 and 5% pet. and tenoxicam 1 and 5% pet. photopatch tests were also performed with piroxicam and tenoxicam. All 10 patients with photosensitivity to piroxicam had positive patch tests to thiosalicylic and thiosalicylic acid and 9 of them had positive photopatch tests to ptroxicam. 20 out of 24 patients with positive patch tests to thiosalicylic acid also had positive photopatch tests to Piroxicam. All the patients tested with salicylic add were negative. Out of the 29 patients with positive photopatch tests to piroxicam, none reacted to tenoxicam. In countries with a high incidence of contact sensitivity to thimerosal/thiosalicylic acid, the use of piroxicam should be avoided and replaced by tenoxicam, a drug without reported photosensitivity