Reconstruction of protein and nucleic acid sequences. I. Systematics and computer program

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Abstract
The protein sequences now known have been reconstructed as a kind of intriguing logical‐mathematical puzzle using information about fragments of the molecules. We wish to show that the reconstruction can be done systematically by repeating a series of elementary operations on these same data governed by a set of well‐defined rules. The completely automatic reconstruction of polymer sequences by a high speed digital computer using these operations and rules is demonstrated.