PROTECTION AGAINST EXPERIMENTAL PROTEUS MIRABILIS PYELONEPHRITIS IN RATS AND SIGNIFICANCE OF IMMUNITY

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Abstract
Intraperitoneal immunization with formalin‐killed bacteria as well as previous hematogenous infection with Proteus O3H1 showed a protective effect against hematogenous pyelonephritis in rats when the homologous strain was used. Transfer of hyperimmune antisera protected against hematogenously induced infection. Neither intravesical or intraperitoneal immunization with formalin‐killed bacteria nor transfer of urines containing antibodies of the IgG class protected against ascending pyelonephritis when the O3H1 strain was used. Data are presented indicating that a rise of pH might decrease the biological effect of antibodies, suggesting that Proteus urease activity is a virulence factor of importance in this context.