LinezolidPenetration into Bone and Joint Tissues Infected withMethicillin-ResistantStaphylococci
Open Access
- 1 December 2003
- journal article
- clinical trial
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (12) , 3964-3966
- https://doi.org/10.1128/aac.47.12.3964-3966.2003
Abstract
Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 ± 2.0 mg/liter.Keywords
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