Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives
- 1 August 1987
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 30 (8) , 1482-1489
- https://doi.org/10.1021/jm00391a034
Abstract
A unique combination of .alpha.2-adrenoreceptor antagonist and serotonin-selective reuptake inhibitory activities has been identified in a series of 2-substituted 4,5-dihydro-1H-imidazole derivatives. This combination of blocking activities has provided one of these derivatives, napamezole hydrochloride (2), with potential as an antidepressant. A discussion of the syntheses of these compounds includes a convenient method for the conversion of nitriles to imidazolines with ethylenediamine and trimethylaluminum.This publication has 6 references indexed in Scilit:
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