Gastric secretion with ulcerogenic islet cell tumor. Importance of basal acid output

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Abstract
Gastric secretory data from 134 patients who satisfied previously established criteria for the diagnosis of ulcerogenic islet cell tumor were analyzed. Basal acid output in this condition was significantly higher than in normal persons or in patients with duodenal ulcer. Maximal acid output following an augmented dose of histamine was significantly above normal, but gastric secretory responses to this and other stimuli did not differ significantly from those in patients with duodenal ulcer, when the stomach was intact, or with marginal ulcer, following gastric surgery. Usually, basal acid output reliably indicated the possible presence of ulcerogenic islet cell tumor; measurements of stimulated gastric secretion and the ratio of basal to stimulated acid output yielded little additional diagnostic information.