The Effects of a Dentifrice Containing Zinc Citrate and 2,4,4' Trichloro‐2'‐Hydroxydiphenyl Ether

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Abstract
The effects of a dentifrice which contained 1% zinc citrate and 0.5% of a nonionic antimicrobial agent, 2,4,4' trichloro‐2'‐hydroxydiphenyl ether on plaque and gingival health have been investigated. In a 4‐day nonbrushing study in which dentifrices were used as slurries, this dentifrice inhibited plaque accumulation significantly more than dentifrices which contained either zinc citrate or Triclosan separately.In a 28‐day double‐blind cross‐over study, a significant reduction in plaque accumulation and improvement in gingival health was demonstrated for the test dentifrice compared to the placebo. The effect was demonstrated with a group of well motivated volunteers who had a good standard of oral health. Analysis of the data suggested that the benefit might be extended to a less motivated population.