ROLE OF PROSTAGLANDINS, HISTAMINE, AND SEROTONIN IN THE PATHO-PHYSIOLOGY INDUCED BY PASTEURELLA HEMOLYTICA ENDOTOXIN IN SHEEP

  • 1 January 1984
    • journal article
    • research article
    • Vol. 12  (1) , 47-59
Abstract
Pasteurella hemolytica endotoxin (12 .mu.g/kg) was infused i.v. into ewes over 500 min. Blood was sampled for 60 min before the infusion and at intervals during the infusion and for 1500 min postinfusion. The control values for plasma TxB2 [thromboxane B2] 6-keto-PGF1.alpha. [6-keto-prostaglandin F1.alpha.], PGF2.alpha. and serotonin were 283 .+-. 53 pg/ml (mean .+-. standard error of mean), 281 .+-. 14 pg/ml, 199 .+-. 27 pg/ml, and 56.8 .+-.2.0 ng/ml, respectively. The plasma concentrations of TxB2, 6-keto-PGF1.alpha., PGF2.alpha. and serotonin significantly increased to a maximum at 50 min infusion to 359, 344, 313 and 201% of the control, respectively. PGF2.alpha. and TxB2 returned to control levels at 300 min during infusion and 6-keto-PGF1.alpha. at 60 min postinfusion and serotonin at 100 min of infusion. Serotonin concentration decreased significantly at 450 min of infusion to 73% of control and returned to control level at 1500 min postinfusion. No significant changes were found in the plasma levels of PGE, histamine and ACE [angiotensin-converting enzyme] activity. Release of TxA2, PGI2, PGF2.alpha., and serotonin may contribute to pathophysiology induced by P. hemolytica endotoxin in sheep.