INHIBITION OF HYPERSENSITIVITY REACTIONS BY 16(S)-METHYL-20-METHOXY-PGE2 (YPG-209) IN ANIMALS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 244  (1) , 157-165
Abstract
The effects of 16(S)-methyl-20-methoxy-PG[prostaglandin]E2 (YPG-209) on hypersensitivity reactions were investigated in the rat, guinea pig and mouse. I.v. YPG-209 was 150 times as potent as disodium cromoglycate (DSCG) in the inhibitory effect on the Ig[immunoglobulin]E(mouse)-mediated 24 h rat PCA [passive cutaneous anaphylaxis]. When administered i.v. to guinea pigs, YPG-209 inhibited significantly the IgE (guinea pig)-mediated 8 day guinea pig PCA, but DSCG exhibited no significant inhibitory effects. The oral doses of YPG-209 diminished both histamine and 5-hydroxytryptamine hypersensitivity of the Bordetella pertussis-treated mice. YPG-209 prevents mediator release and antimediator effect in laboratory animals.