Distribution of Active Gene Sequences: A Subset Associated with Tightly Bound Chromosomal Proteins
- 8 February 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4431) , 661-662
- https://doi.org/10.1126/science.7352280
Abstract
The distribution of active polyadenylate-messenger RNA sequences in fractionated chicken liver chromatin was examined. A portion of these active gene sequences is concentrated in a DNA fraction retained by tightly bound nonhistone chromosomal proteins, while the nonretained DNA fraction is substantially depleted of a portion of these sequences. These findings suggest that the tightly bound nonhistones are physically associated with a subset of active gene sequences.Keywords
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