Studies on Copper-Induced Ovulation in the Rabbit
- 1 May 1964
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 74 (5) , 780-783
- https://doi.org/10.1210/endo-74-5-780
Abstract
Induction of ovulation by means of intravenously administered cupric gluconate was tested in nonpregnant, pseudopregnant and pregnant rabbits. In nonpregnant, estrogen-pretreated rabbits, injection of more than 4 mg/kg of the compound induced ovulation in all the animals. Ovulation in these rabbits was not induced by 9 hr, but occurred between 10 and 13 hr postinjection. In pregnant and pseudopregnant animals, ovulation could not be induced by the injection of cupric gluconate, indicating a central rather than a peripheral action of this compound and suggesting inhibition of the copperactivated ovulation mechanism by humoral agents characteristic of pregnancy. (Endocrinology74: 780, 1964)Keywords
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