Abnormal Coronary Function in Mice Deficient in α 1H T-type Ca 2+ Channels
- 21 November 2003
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5649) , 1416-1418
- https://doi.org/10.1126/science.1089268
Abstract
Calcium ion (Ca 2+ ) influx through voltage-gated Ca 2+ channels is important for the regulation of vascular tone. Activation of L-type Ca 2+ channels initiates muscle contraction; however, the role of T-type Ca 2+ channels (T-channels) is not clear. We show that mice deficient in the α 1H T-type Ca 2+ channel (α 1 3.2-null) have constitutively constricted coronary arterioles and focal myocardial fibrosis. Coronary arteries isolated from α 1 3.2-null arteries showed normal contractile responses, but reduced relaxation in response to acetylcholine and nitroprusside. Furthermore, acute blockade of T-channels with Ni 2+ prevented relaxation of wild-type coronary arteries. Thus, Ca 2+ influx through α 1H T-type Ca 2+ channels is essential for normal relaxation of coronary arteries.Keywords
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