Effects of Two Calculated Plasma Sufentanil Concentrations on the Hemodynamic and Bispectral Index Responses to Mayfield Head Holder Application

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Abstract
The effects of two calculated plasma sufentanil (SUF) concentrations on the hemodynamic and bispectral index (BIS) responses to Mayfield head holder (MH) application were studied in 20 patients scheduled for intracranial surgery. Premedication consisted of hydroxyzine, alprazolam, and atropine given orally 1 hour before surgery. Anesthesia was provided with propofol (PPF) and SUF using a target-controlled infusion device. Patients were randomly assigned to one of two groups according to calculated plasma concentrations: 3 μg/mL-1 of PPF and 0.5 ng/mL-1 of SUF in group I (GI) and 3 μg/mL-1 of PPF and 1 ng/mL-1 of SUF in group II (GII). The MH was fixed 33.0 ± 6.6 minutes (mean ± SD) after induction. Systolic (SAP), diastolic (DAP), and mean arterial pressure (MAP) as well as heart rate (HR) and BIS were recorded 1 minute before pinning (baseline) as well as 1 minute (P1), 2 minutes (P2), and 3 minutes (P3) after pinning. Multivariate repeat-measured analyses of variance were applied to the baseline-subtracted measurements of hemodynamic and BIS values. Groups were compared using the Student's t test, and P -1

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