FAILURE OF VAGOTOMY TO PREVENT THE FORMATION OF MANN-WILLIAMSON ULCERS IN DOGS

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Abstract
THE MANN-WILLIAMSON procedure of internal duodenal drainage is recognized as a convenient and consistent method of producing experimental peptic ulcers.1 In from 90 to 100 per cent of dogs so prepared chronic progressive ulcers resembling the spontaneous ulcers of the stomach and duodenum in man develop. The availability of an experimental procedure which leads to the development of a specific disease in such a high percentage of cases obviously provides a most useful test object for the therapeutic effectiveness of various types of treatment. While this method was not employed by Dragstedt and his associates2 when they introduced complete gastric vagotomy for the treatment of peptic ulcer in man, it has since been employed almost simultaneously in a number of different laboratories as a check on results coming from the clinic. During the progress of the present study, several workers have published results from similar experiments. Harkins and

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