Circadian Variation in Plasma Iron Concentration and Reticuloendothelial Iron Release in the Rat

1 September 1973

journal article
Published by Portland Press Ltd. in Clinical Science

Vol. 45 (3) , 331-336
https://doi.org/10.1042/cs0450331

Abstract

1. As in man, the plasma iron concentration in rats exhibits a circadian variation, with an early morning peak and an evening trough. 2. The release into the plasma of iron liberated from haemoglobin within the reticuloendothelial cells of the liver and spleen was studied by injecting heat-damaged erythrocytes containing ⁵⁹Fe-labelled haemoglobin. 3. The percentage of ⁵⁹Fe released was lower in the morning than in the evening. 4. These observations suggest that a circadian variation in reticuloendothelial cell behaviour influences the plasma iron concentration.

Keywords

PLASMA IRON
CIRCADIAN VARIATION
HAEMOGLOBIN IRON RELEASE
RETICULOENDOTHELIAL CELL FUNCTION

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