GALENICAL DEVELOPMENT OF A NEW SUSTAINED-RELEASE THEOPHYLLINE PELLET FORMULATION FOR ONCE-DAILY ADMINISTRATION

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  • 1 August 1988
    • journal article
    • research article
    • Vol. 38-2  (8A) , 1203-1209
Abstract
Euphylong is a sustained-release product consisting of encapsulated pellets covered with a porous membrane. Since the mechanism of release is osmotic, this new formulation has been termed a "micro-osmotic system". The course of theophylline release is linear over a wide range and is independent of pH value, surface tension and buffer concentration of the dissolution medium. Furthermore, the in-vitro release remains largely uninfluenced by the dissolution model used and by agitation of the dissolution medium. Variations in the in-vitro release profiles produce variations in the in-vivo absorption profiles determined by deconvolution. It is therefore possible, irrespective of the dissoluton model and medium used, to produce in in-vitro release profiles that enable in-vivo absorption to be predicted by varying the thickness or porosity of the membrane.