Nighttime and daytime efficacy of flurazepam and oxazepam in chronic insomnia

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Abstract
Trials of hypnotic medications typically determine efficacy by examining changes in polysomnographically recorded sleep and in daytime performance. Daytime sleepiness was used as a new, potentially crucial criterion in such trials. Oxazepam (O) and flurazepam [F] were effective im improving some polysomnographically defined measures of nocturnal sleep in 14 patients with chronic insomnia; F produced substantial daytime sleepiness and O did not. O produced some rebound insomnia consisting of .apprx. 1 h reduction of polysomnographically defined sleep but without gross mood disturbance or the patients'' awareness of sleep loss.