Effects of Feeding Autoclaved Pancreas to Depancreatized and Duct-Ligated Dogs.

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Abstract
Autoclaved pancreas, liver, brain, and salivary glands were fed to insulin treated depancreatized dogs and dogs with ligated pancreatic ducts. Measurements were made of the body wt., serum lipids, alkaline phosphatase of the serum, histological evidence of liver fat in specimens obtained by needle biopsy, and the amt. of insulin required daily to prevent glycosuria. Autoclaved pancreas was effective in preventing and curing fatty infiltration of the liver and other evidences of lipocaic insufficiency, while the other autoclaved tissues were entirely inert. Thus, the active principle in pancreas, lipocaic, is relatively heat resistant, and is accordingly not trypsin or any of the known panoreatic enzymes. The active principle in pancreas is not one of the known lipotropic agents such as choline, methionine, or inositol, or a combination of them, since these substances are present in liver, brain, and salivary glands in amts. roughly equivalent to that in pancreas.

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