The what, why and how of bayesian clinical trials monitoring
- 15 July 1994
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 13 (13-14) , 1371-1383
- https://doi.org/10.1002/sim.4780131312
Abstract
We discuss the advantages and limitations of group sequential methods for monitoring clinical trials data. We describe a Bayesian approach, based upon the use of sceptical prior distributions, that avoids some of the limitations of group sequential methods. We illustrate its use with data from a trial of levamisole plus 5‐Fluorouracil for colorectal cancer.Keywords
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