How to Synthesize A tRNA?
- 1 May 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 14 (3) , 843-846
- https://doi.org/10.1080/15257779508012485
Abstract
New blocking group combinations have been investigated to achieve an automated synthesis of a tRNA and structural analogs on solid-support. The use of the 4-methoxytetrahydropyranyl group for 2′-OH-protection and the dansylethoxycarbonyl group for the 5′-OH position shows in the phosphoramidite approach good results. In the arabino series the 2-(4-nitrophenyl)ethoxycarbonyl group is a perfect 2′-OH blocking group which can be combined with the dimethoxytrityl residue in the usual manner to give high yields and pure materials.Keywords
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