Cefazolin Treatment of Bacterial Infections

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Abstract
Cefazolin sodium was used to treat 20 serious bacterial infections in 19 patients, 11 of whom were infected with coagulase-positive Staphylococci. Clinical and bacteriologic success were initially obtained in 15 patients with 16 infections. 2 additional patients were cured after surgery for removal of foreign bodies and a second course of the antibiotic. 1 asplenic patient had bacteremia and died 5 days after initiating therapy with negative blood cultures and multiple abscesses. 1 patient with endocarditis relapsed 19 months after treatment with 6 weeks of cefazolin and prolonged oral antibiotics. Calculated median, trough, free drug levels were 1.5–15.3 times the minimum inhibitory concentration for 27 of 29 pathogens.

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