Differential β‐arrestin binding of AT1and AT2angiotensin receptors
- 6 December 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (1) , 41-45
- https://doi.org/10.1016/j.febslet.2005.11.044
Abstract
Agonist stimulation of G protein‐coupled receptors causes receptor activation, phosphorylation, β‐arrestin binding and receptor internalization. Angiotensin II (AngII) causes rapid internalization of the AT1receptors, whereas AngII‐bound AT2receptors do not internalize. Although the activation of the rat AT1Areceptor with AngII causes translocation of β‐arrestin2 to the receptor, no association of this molecule with the AT2receptor can be detected after AngII treatment with confocal microscopy or bioluminescence resonance energy transfer. These data demonstrate that the two subtypes of angiotensin receptors have different mechanisms of regulation.Keywords
This publication has 25 references indexed in Scilit:
- Human prostaglandin EP3 receptor isoforms show different agonist‐induced internalization patternsFEBS Letters, 2004
- Oligomerization of Wild Type and Nonfunctional Mutant Angiotensin II Type I Receptors Inhibits Gαq Protein Signaling but Not ERK ActivationPublished by Elsevier ,2004
- Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling PathwaysPhysiological Reviews, 2004
- Structural determinants of agonist-induced signaling and regulation of the angiotensin AT1 receptorPublished by Elsevier ,2003
- N-Formyl Peptide Receptors Internalize but Do Not Recycle in the Absence of ArrestinsJournal of Biological Chemistry, 2003
- Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptorThe Journal of cell biology, 2002
- Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of ReceptorsJournal of Biological Chemistry, 2000
- Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor InternalizationJournal of Biological Chemistry, 1996
- The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclaseBiochemical and Biophysical Research Communications, 1992
- Isolation of a cDNA encoding the vascular type-1 angiotensin II receptorNature, 1991