Thiocarbamates as Novel Backbone Analogs in Oligonucleotides
- 1 January 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (01) , 108-110
- https://doi.org/10.1055/s-1995-4846
Abstract
The synthesis of a thymidine dimer containing a thiocarbamate moiety as internucleosidic linkage replacement is described. This new dimer was incorporated in oligodeoxyribonucleotides and the melting temperatures (Tm’s) of the DNA/RNA duplexes were determined.Keywords
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