Refined Three-Dimensional Structure of Cat-Muscle (M1) Pyruvate Kinase at a Resolution of 2.6 Å
- 1 May 1996
- journal article
- Published by International Union of Crystallography (IUCr) in Acta Crystallographica Section D-Biological Crystallography
- Vol. 52 (3) , 499-504
- https://doi.org/10.1107/s0907444995016040
Abstract
The three-dimensional structure of cat-muscle pyoruvate kinase has been refined at a resolution of 2.6 A. The details of the structure permit interpretation of the original heavy-atom studies and give insight into the importance of conserved residues in pyruvate kinases and the allosteric behaviour of the enzyme. There are a small number of essential residues which determine the relative orientations of domains and the precise nature of intersubunit contacts. Arginine residues are particularly important.Keywords
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