In vivo1H, 31P‐{1H} and 13C‐{1H} magnetic resonance spectroscopy of malignant histiocytoma and skeletal muscle tissue in man

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Abstract
Human tumor and skeletal muscle tissue was studied by means of in vivo1H, 31P, and 13C MRS. The examinations were performed with a 1.5 T whole‐body MR scanner equipped with a second RF system. Localized 1H and broadband proton‐decoupled 31P and 13C MR spectra were obtained in measurement times of 5, 10 and 33 min, respectively, from a malignant fibrous histiocytoma in a patient and from gastrocnemius muscle tissue in healthy volunteers. Proton decoupling enhanced the sensitivity (via the nuclear Overhauser effect) and the information available from in vivo31P and 13C MR spectra significantly. The most information was obtained from 1H‐decoupled 31P spectra. Observation of more than one spin species allows peak assignments to be verified mutually. The spectral data of the histiocytoma differ largely from that of muscle tissue and show a tumor with elevated pH value, normal level of nucleoside 5′‐triphosphates, and high level of compounds involved in phospholipid turnover. The multinuclear in vivo MRS experiment may allow the non‐invasive observation of almost the complete pathway of phospholipid synthesis and degradation in intact human tissue.