IMMUNOPHARMACOLOGIC PROPERTIES OF WY-16, 922, A NEW ORALLY EFFECTIVE ANTIALLERGIC AGENT

  • 1 January 1976
    • journal article
    • research article
    • Vol. 197  (3) , 725-733
Abstract
In a series of tests designed to illustrate immune reactions similar to those obtained in atopic disease, Wy-16,922 effectively inhibited reaginic-mediated immunologic reactions in the skin, lungs and mast cell. It was found to be devoid of immunosuppressant, antimediator, anti-inflammatory, steroid or bronchodilator properties as well as acute toxicity. Although the mechanism of action of Wy-16,922 is unknown, it appears to limit the release (not the effects) of allergic mediators in a manner similar to that described for disodium cromoglycate.

This publication has 0 references indexed in Scilit: