An Electronic Method of Detecting Blood Volume Changes

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Abstract
Blood volume changes of approximately 5 to 10% of total blood volume have been accurately detected in animals ranging in size from 2.5 to 27.0% using an electronic method which is based on changes in total body impedance. Linearity of the method was excellent within the limits of a 20% blood volume depletion which was not exceeded in order to avoid hemorrhagic shock. A 10% volume change represents a change in body impedance of approximately 1.5 ohms. In order to detect such a small change, the electronic apparatus must be capable of very high gain, with minimal drift. The method offers promise as a useful operating room tool, since it gives an instantaneous indication of blood volume change.

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