Synthesis of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a potent mutagen
- 1 April 1985
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 63 (4) , 828-832
- https://doi.org/10.1139/v85-137
Abstract
Starting from tetrachloroacetone 1 and (carbomethoxymethylene)triphenylphosphorane 4, the title compound 16 was prepared in five steps in 44% yield. Spectroscopic and chromatographic data indicated that this material was identical to a potent mutagen isolated from kraft pulp chlorination effluent. Various mutant Salmonellatyphimurium strains (TA 98, 100, and 1537) behaved similarly when incubated with either 16 or the isolated mutagen.This publication has 4 references indexed in Scilit:
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