The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells.

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Abstract
The proliferative response of mouse B [bone marrow-derived] lymphocytes induced by Fc fragments was dependent upon an adherent cell population. The adherent cell was esterase positive, irradiation resistant and not susceptible to lysis by anti-thymus serum and complement. The mechanism(s) by which Fc fragments induced B cell proliferation could be the result of the interaction of Fc with B cells and adherent cells or with adherent cells which then release factors that trigger the B cells to proliferate. Spleen cells from the C3H/HeJ mouse were unable to respond to Fc fragments. The addition of adherent cells from C3H/St or C3H/HeN mice to adherent cell depleted C3H/HeJ cells enabled them to respond to Fc, indicating the defect was in the adherent cell population.