Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 4 (11) , 1491-1494
- https://doi.org/10.1093/carcin/4.11.1491
Abstract
Hepatic DNA damage was demonstrated by alkaline DNA unwinding/hydroxylapatite batch chromatography in male B6C3F1 mice treated with non-necrogenic doses of 1,2-di-chloroethane, l-bromo-2-chloroethane, and 1,2-dibromo-ethane. Intraperitoneal administration of 0.5 mmol/kg of l-bromo-2-chloroethane and 1,2-dibromoethane produced similar levels of DNA damage. A 4-fold higher dose of 1,2-di-chloroethane (2.0 mmol/kg) was required to produce a comparable effect.Keywords
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