A Follow-up Magnetic Resonance Imaging Study of Schizophrenia
Open Access
- 1 February 1998
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 55 (2) , 145-152
- https://doi.org/10.1001/archpsyc.55.2.145
Abstract
CROSS-SECTIONAL computed tomographic1 and magnetic resonance imaging (MRI)2-6 studies have reported decreased brain volume in schizophrenia, affecting frontal2,3 and temporal4-6 regions. Abnormalities in patients with first-episode (FE) schizophrenia support a neurodevelopmental hypothesis because brain dysfunction precedes clinical presentation. However, a longitudinal design is necessary to examine the progressive deterioration suggested by the neurodegenerative hypothesis.Keywords
This publication has 1 reference indexed in Scilit:
- Implications of Normal Brain Development for the Pathogenesis of SchizophreniaArchives of General Psychiatry, 1987