The Activity of Anionic Surface Active Compounds in Producing Vascular Obliteration

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Abstract
The effectiveness of anionic wetting agents and some soaps in producing thrombosis and subsequent obliteration of veins was investigated by injecting these materials into the tail vein of mice. A dose response curve was obtained which made the quantitative comparison of various agents possible by plotting the avg. length of the thrombus formed against the logarithm of the dose. Sodium 2-methyl-7-ethyl-undecyl sulfate-4 (I) and di-2-ethylhexyl sodium sulfosuccinate (II) were more effective in producing thrombus than Na ricinoleate (III) and Na morrhuate (IV), the latter being the least effective of the compounds tested. Branched chain anionic wetting agents were, as a rule, more effective than the straight chain compounds. The acute toxicity by intravenous injn. in mice was (I) 90 [plus or minus] 5 mg/kg, (II) 100 [plus or minus] 30 mg/kg, (III) 100 [plus or minus] 3 mg/kg, and (IV) 140 [plus or minus] 45 mg/kg. (I) was less irritating than (III) and (IV) when injected subcut.

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