Inhibition of fatty acid beta oxidation by influenza B virus and salicylic acid in mice

1 February 1988

journal article
research article
Published by Wolters Kluwer Health in Neurology

Vol. 38 (2) , 239
https://doi.org/10.1212/wnl.38.2.239

Abstract

Injection of concentrated influenza B/Lee/40 virus into 4-week-old Balb C mice resulted in 60% inhibition of ¹⁴C-palmitate oxidation in isolated hepatic mitochondria. Oral feeding of carnitine to infected mice prevented the inhibition of fatty acid oxidation. High concentrations of salicylic acid given orally also inhibited ¹⁴C-palmitate oxidation. Serum free fatty acid concentrations of infected mice and of those fed salicylic acid were significantly higher than in control mice. A combination of low-dose virus and low-dose salicylic acid inhibited palmitate oxidation, suggesting an additive effect on the metabolic derangement when the two agents were present simultaneously.

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