Combined Anesthesia and Hyperimmune Serum Therapy in the Treatment of Experimental Western Equine Encephalomyelitis

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Abstract
Either intraperit. injn. of hyperimmune rabbit serum or deep ether anesthesia administered beginning 18 hrs. following intracerebral inoculation of virus effects a significant change in survival rate among Swiss mice infected with western equine encephalomyelitis. That amt. of virus was used which produced encephalitis in 80% of the control animals. 20% of the control animals survived the observation period of 10 days as compared with 52% of the serum-treated animals and 61.5% of the etherized animals. A combination of the 2 methods was more effective than either method alone, resulting in a survival of 90.7% of the animals.

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