Abstract
Deficiency of the normal stability of lung expansion which is contingent upon the activity of a peculiar, area-dependent surfactant at the respiratory surfaces, occurs in a variety of pathologic and experimental conditions. Examples from spontaneous and induced disease in laboratory animals are reported, and others in man and animals are gleaned from the literature. It is therefore desirable to include in investigations of pulmonary pathology determinations of either surface activity of lung extracts or pressure-volume studies of whole lungs or lobes.

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