Benzastatins A, B, C, and D: New Free Radical Scavengers from Streptomyces nitrosporeus 30643. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.
- 1 January 1996
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 49 (1) , 20-25
- https://doi.org/10.7164/antibiotics.49.20
Abstract
In the course of screening for free radical scavengers, rare metabolites, benzastatins A and B having aminobenzamide skeleton and benzastatins C and D having tetrahydroquinoline skeleton, were isolated from the culture broth of streptomyces nitrosporeus 30643. They showed inhibitory activity against lipid peroxidation in rat liver microsomes. In the cell assay, benzastatins C and D inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 2.0 and 5.4 microM, respectively.Keywords
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