Effect of d-Lysergic Acid Diethylamide on Spinal Reflexes

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Abstract
Spinal segmental reflexes were studied in unanesthetized cats using electrophysiological techniques. Monosynaptic and polysynaptic reflex activity was recorded in ventral root discharges resulting from stimulation of gastrocnemius, tibial or peroneal nerve. The amplitude of the monosynaptic reflex was found to be increased following intravenous injection of doses greater than 200 ug/kg d-lysergic acid diethylamide. Polysynaptic activity was depressed. These results were discussed in terms of present day concepts of anatomical connections and neurohumoral transmitter processes in the central nervous system.