A Simple Method for Amide Formation from Protected Amino Acids and Peptides
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (01) , 37-39
- https://doi.org/10.1055/s-1989-27139
Abstract
Amide formation from protected amino acids and peptides is directly and simply achieved by using 1-hydroxybenzotriazole as activating agent and treating the intermediate O-(benzotriazol-1-yl) derivative ("active ester") in situ with 25% ammonium hydroxide solution.Keywords
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