Hypothalamic-Pituitary Gonadal Dysfunction in Renal Failure, Dialysis and Renal Transplantation*

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Abstract
Introduction THE REGULARITY of gonadal dysfunction in patients with chronic renal failure and in particular the dramatic reversal of hypogonadism after successful renal transplantation are of theoretical and practical interest in the understanding of the regulation of normal and abnormal gonadal function. It is the purpose of this review to summarize available knowledge of the function of the hypothalamic-pituitary gonadal axis in uremia. Specific emphasis is directed towards the derangements of testicular function in uremia and the central as well as gonadal disturbances operative. In addition the parallel abnormalities of the ovarian, thyroidal, adrenal and somatotropin axes in uremia are also considered. Finally, specific factors implicated in the pathogenesis of uremic hypogonadism are evaluated.

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