Carboxypeptidase activity in the insulin secretory granule
- 3 October 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 162 (1) , 137-141
- https://doi.org/10.1016/0014-5793(83)81065-5
Abstract
Carboxypeptidase activity was studied in subcellular fractions from a transplantable rat insulinoma and found to be localised principally in the insulin secretory granule. The activity, which was specific for peptide substrates with C-terminal basic amino acids, appeared to be a single enzyme with M r 54 000. This enzyme differed with respect to size and pH optimum from other basic amino acid-specific carboxypeptidases, such as carboxypeptidases B and N, and may be a secretory granule-specific enzyme involved in propolypeptide processing.Keywords
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