A family showing both dystrophia myotonica and spastic paraplegia

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Abstract
A family with dystrophia myotonica in 3 successive generations is presented. Cataract occurred in the generation preceding them. Collectively the affected patients show all the classical features of dystrophia myotonica, including endocrine and cardiac manifestations. The results of enzyme studies on some of the affected members of the family are also briefly discussed. The feature of unusual interest in this family is the occurrence of spastic paraplegia in 1 of the patients with dystrophia myotonica and the transmission of the spastic paraplegia to his 2 sons, who so far show no evidence of dystrophia myotonica. However, it is not suggested that the 2 conditions in this family are causually related but that this is likely to be due to chance.

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