Plasma catecholamine levels in the coronary sinus, the left renal vein and peripheral vessels in healthy males at rest and during exercise

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Abstract
Noradrenaline [norepinephrine] and adrenaline [epinephrine] were determined in blood samples from the brachial vein, brachial artery, left renal vein and femoral vein in 6 healthy males (aged 23-35 yr). In 3 subjects catecholamines were determined also in blood from the coronary sinus. All samples were taken simultaneously in supine position after 30 min of rest and then among exercise in supine position using a bicycle ergometer, 1st with a work load of 50 W for 9 min and then with a work load of 150 W for the same period of time. Under resting conditions catecholamine levels were about the same at all locations; the mean for noradrenaline was 1.59 nmol/l with a range of 1.30-2.11 nmol/l and for adrenaline 0.46 nmol/l and 0.23-0.65 nmol/l, respectively. At 50 W the noradrenaline concentration increased significantly in the brachial artery, left renal vein and femoral vein and adrenaline increased significantly only in the femoral vein. At 150 W the noradrenaline content increased markedly in all samples, especially in the left renal vein (mean increase 13.02 nmol/l) and the coronary sinus (mean increase 13.06 nmol/l). Adrenaline concentration increased significantly in the brachial artery and the femoral vein. At 150 W the mean net output of noradrenaline as estimated from calculated flows and actual anteriovenous differences were 2.25 nmol/min from the heart and 0.36 nmol/min from the kidney.