Increased Alveolar-Capillary Membrane Permeability by Monocrotaline.

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Abstract
To study the effect of monocrotaline on the pulmonary alveolar-capillary membrane permeability, cardiac catheterization, extravascular lung water content and absorption of 14C-compounds from the rat lungs in combination with morphological observations were studied in the early stage of monocrotaline intoxication. Purified monocrotaline or its pyrrole was administered to rats with various doses. Single dose of 50 mg/kg monocrotaline was enough to induce pulmonary hypertension 4 wk later but immediate or direct pressor effect was not observed by monocrotaline or active pyrrole. Only 3-5 mg/kg of pyrrole was enough to produce alveolar flooding with increased extravascular lung water content and accelerated absorption of 14C-mannitol and 14C-inulin from lungs 24 h after administration. In contrast with fast and potent effect of pyrrole, effect of monocrotaline was mild and delayed in development. Monocrotaline increased the porosity of endothelial and alveolar membrane by its active metabolite.

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