PARALLEL TUBULAR ARRAYS IN SEVERE COMBINED IMMUNODEFICIENCY DISEASE - ULTRASTRUCTURAL-STUDY OF PERIPHERAL-BLOOD LYMPHOCYTES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 50  (1) , 55-64
Abstract
The ultrastructure of lymphocytes from 3 children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53, 41 and 13%) in 3 SCID patients when compared to age-matched controls. The size of these inclusions was quite variable, with some attaining a length of 1.7 .mu.m. They contained a tubular substructure with a diameter of 36-44 nm. The PTA were mostly located in the centriolar and Golgi regions of the cytoplasm and were sometimes membrane bound. A centriolor origin of the inclusion was suggested. A 2nd inclusion, the tubuloreticular structure, was found only in 1.4% of the circulating lymphocytes from 1 SCID patient. The origin of the PTA and its occurence in SCID are discussed.

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