Enzymuria (the Output of Gamma-Glutamyl-Transpeptidase and of N-Acetyl-Beta-D-Glucosaminidase) in the Course of Experimental Renovascular Hypertension

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Abstract
The urinary output of γ-glutamyl-transpeptidase (γGT) and of N-acetyl-β-D-glucosaminidase (NAG) was studied in rats with ‘two-kidney Goldblatt hypertension’ 3-6, 16-19 and 30-33 weeks after eliciting high blood pressure. γGT excretion rate of normotensive males was higher than that of females, while the activity of the renal tissue was on the same level. γGT output of hypertensive males was elevated in the early and in the middle stages of the disease, it was subnormal in the late stage. In females γGT output increased in animals with excessively high blood pressure (> 200 mm Hg) only. γGT output correlated with the tissue activity in males only. In all animals there was an inverse, linear correlation between tissue γGT activity and the hydroxyproline content. The pattern of the NAG output was similar to that of γGT, however, excretion of NAG showed no sex differences and remained high in the late stage of the disease, too. Nephrosclerosis was less pronounced in female Goldblatt rats than in males.