Anencephalus in the Oxford Record Linkage Study Area

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Abstract
The incidence of anencephalus in the largely rural areas of Oxfordshire and W Berkshire, England, from 1965-1972 was ascertained from the files of the Oxford Record Linkage Study as 1.49/1000 births. There was little variation within the area, but there was a marked increase in incidence over the 8 yr of the study. There was a slight seasonal variation, with an excess of conceptions in the 1st 2 quarters of the year, a slight excess of births to primiparous women and to women aged between 20-24 yr. There was an increase in incidence with falling social class, with a significant excess of fathers who were printers, painters and decorators, transport drivers or in the armed forces. Among 115 siblings, 11 (9.6%) had CNS defects, and the incidence of anencephalus among twins was twice as high as expected.

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