An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein–Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness
- 1 April 2003
- journal article
- research article
- Published by Elsevier in Mechanisms of Ageing and Development
- Vol. 124 (4) , 477-485
- https://doi.org/10.1016/s0047-6374(03)00026-5
Abstract
No abstract availableKeywords
Funding Information
- Deutsche Forschungsgemeinschaft (Pa 361/7-1)
- Bundesministerium für Bildung und Forschung
- Stiftung VERUM
- European Commission (QLK6-1999-02031, QLK6-CT-2001-02283)
This publication has 46 references indexed in Scilit:
- Is human immunosenescence clinically relevant? Looking for ‘immunological risk phenotypes’Trends in Immunology, 2002
- HUMAN CYTOTOXIC T LYMPHOCYTE RESPONSES TO EPSTEIN-BARR VIRUS INFECTIONAnnual Review of Immunology, 1997
- Phenotypic Analysis of Antigen-Specific T LymphocytesScience, 1996
- Expansion of cytotoxic CD8+ CD28− T cells in healthy ageing people, including centenariansImmunology, 1996
- Immune Parameters in a Longitudinal Study of a Very Old Population of Swedish People: A Comparison Between Survivors and NonsurvivorsThe Journals of Gerontology: Series A, 1995
- Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.The Journal of Experimental Medicine, 1995
- Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIVNature, 1994
- Effect of Age on Cytotoxic T Lymphocyte Memory as well as Serum and Local Antibody Responses Elicited by Inactivated Influenza Virus VaccineThe Journal of Infectious Diseases, 1993
- Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies.The Journal of Experimental Medicine, 1992
- The Involution of the Ageing Human Thymic Epithelium is Independent of PubertyScandinavian Journal of Immunology, 1985